National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10589-j

Testing Status of 2,4,5-Trimethylaniline - 10589-J

 

CASRN: 137-17-7

Formula: C9-H13-N

Synonyms/Common Names

  • 2,4,5-Trimethylbenzenamine (9CI)

Known Uses

Synthesis of the dye Ponceau 3R.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02299)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1000, 4600, M: 0, 25, 1000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02299)  Report Complete 
    • TR-160 (NIH Number: 79-1716)  (Peer Review Approval 12/13/1978A )
      Bioassay of 2,4,5-Trimethylaniline for Possible Carcinogenicity (CASRN 137-17-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Equivocal 
      • Female Mice Positive 
    • Dose: R: 0, 200, 800, M: 0, 50, 100 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (005305)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (070773)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (175438)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.