National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10590-g

Testing Status of Ziram - 10590-G

 

CASRN: 137-30-4

Formula: C6-H12-N2-S4-Zn

Synonyms/Common Names

  • (T-4)-Bis(dimethyldithiocarbamato-S,S')zinc (9CI)

Known Uses

Fungicide & accelerator in rubber vulcanization.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C50442)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C50442)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 300, 600, 1200, 2500, OR 5000 PPM.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C50442)  Report Complete 
    • TR-238 (NIH Number: 83-1794)  (Peer Review Approval 12/16/1981A )
      Carcinogenesis Bioassay of Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: R: 0, 300, OR 600 PPM M: 0, 600, OR 1200 PPM.

Genetic Toxicology

  • Chromosome Aberrations  (880520)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (054163)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Drosophila  (075511)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (746976)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (356540)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Sister Chromatid Exchanges  (880520)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.