Testing Status of Benzyl acetate 10591-K

 

CASRN: 140-11-4

Formula: C9-H10-O2

Synonyms/Common Names

  • Acetic acid, phenylmethyl ester

Known Uses

Soap fragrance; flavoring ingredient; solvent for cellulose acetate and cellulose nitrate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. And as a component of printing inks and varnish removers.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C06508A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C06508A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&MM: 0, 62.5, 1000, FM: 0, 125, 2000 MG/KG/10 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C06508B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&MM: 0, 62.5, 1000, FM: 0, 125, 2000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C06508A)  Report Complete 
    • TR-250 (NIH Number: 86-2506)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 250, 500, M: 0, 500, 1000 MG/KG/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C06508B)  Report Complete 
    • TR-431 (NIH Number: 93-3162)  (Peer Review Approval 12/01/1992A )
      Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 0.3, 0.6, 1.2%, M: 0, 0.033, 0.1, 0.3%/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0072)  Completed 
    • Citation: Abdo KM, Huff JE, Haseman JK, Boorman GA, Eustis SL, Matthews HB, Burka LT, Prejean JD, Thompson RB. Benzyl acetate carcinogenicity, metabolism, and disposition in Fischer 344 rats and B6C3F1 mice. Toxicology. 1985 Oct;37(1-2):159-70.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice; Male and Female Rats: F344/N; Male and Female Mice
    • Dose: R/PO:25, 500; M/PO:500, 1000; R/IV:5; M/IV:10MG/KG.
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0441)  Completed 
    • Citation: McMahon TF, Diliberto JJ, Birnbaum LS. Age-related changes in the disposition of benzyl acetate. A model compound for glycine conjugation. Drug Metab Dispos. 1989 Sep-Oct;17(5):506-12.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: C57BL/6
  • Toxicokinetic Study (Dosed-Feed; Gavage)  (S0319)  Completed 
    • Citation: Yuan JH, Goehl TJ, Abdo K, Clark J, Espinosa O, Bugge C, Garcia D. Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice. Food Chem Toxicol. 1995 Feb;33(2):151-8.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: GAVAGE - 500 MG/KG (RAT) AND 1000 MG/KG (MICE) FEED - 10, 800 PPM (RATS) AND 2700 PPM (MICE).

Genetic Toxicology

  • Chromosome Aberrations  (500814)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (453123)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (034451)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (311211)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Mouse Lymphoma  (351266)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (432849)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A89285)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (883303)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (500814)  Completed 
    • Mice
    • Sister Chromatid  Negative