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Testing Status of Ethyl acrylate 10594-X

 

CASRN: 140-88-5

Formula: C5-H8-O2

Synonyms/Common Names

  • 2-Propenoic acid, ethyl ester (9CI)

Known Uses

Production of paints, paper, fabrics, dirt release agents, and specialty plastic; ingredient in flavoring and fragrance.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C50384)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C50384)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 7, 110, M: 0, 12, 100 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 107 weeks (Gavage)  (C50384)  Completed 
    • TR-259 (NIH Number: 87-2515)  (Peer Review Approval 02/28/1983A )
      Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C50384)  Completed 
    • TR-259 (NIH Number: 87-2515)  (Peer Review Approval 02/28/1983A )
      Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 100, 200 MG/KG/50 PER GROUP.

Special Studies

  • Cell Proliferation (Gavage)  (S0287)  Completed 
    • Citation: Ghanayem BI, Matthews HB, Maronpot RR. Sustainability of fore stomach hyperplasia in rats treated with ethyl acrylate for 13 weeks and regression after cessation of dosing. Toxicol Pathol. 1991;19(3):273-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Cell Proliferation (Gavage)  (S0368)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Role of chemically induced cell proliferation in ethyl acrylate-induced forestomach carcinogenesis. Prog Clin Biol Res. 1991;369:337-46.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Cell Proliferation (Gavage)  (S0746)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. I. Effect of single and repetitive dosing. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):323-35.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Cell Proliferation (Gavage)  (S0747)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. III. Development and recovery of lesions. Toxicol Appl Pharmacol. 1986 May;83(3):576-83.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Cell Proliferation (Gavage)  (S0748)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Effects of sulfhydryl modulation on ethyl acrylate-induced forestomach toxicity. Toxicol Lett. 1991 Feb;55(2):215-21.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Cell Proliferation (Gavage)  (S0757)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N
  • Mechanisms (Gavage)  (S0467)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. II. Structure-toxicity relationships and mechanism. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):336-44.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Gavage)  (S0369)  Completed 
    • Citation: Ghanayem BI, Burka LT, Matthews HB. Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fisher 344 rats. Fundam Appl Toxicol. 1987 Oct;9(3):389-97.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100, 200, 400 mg/kg.
  • Metabolism  (S0780)  Completed 
    • Citation: Project Report No . 2 Metabolism of Ethyl Acrylate in the Stomachs of Male and Female Fischer 344 Rats Dates of Study: November - December 1982 Pharmacokinetics of Xenobiotics December 1982
    • Male and Female Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (272157)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (402439)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (550589)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (177932)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (518545)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (270996)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (324746)  Completed 
    •  Negative 
  • Salmonella  (623002)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (749805)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (840926)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (272157)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • 4 days, 8 days Immunotoxicity (Topical Application)  (IMM95004)  Completed 
    • Female Mice: B6C3F1
    • Dose: 10, 20, AND 30% IN ACETONE (99.8%) FOR SENSITIZATION AND 30% FOR CHALLENGE; 0.25% DNFB AS POSITIVE CONTROL AND 0.5% FOR CHALLENGE.