National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10596-f

Testing Status of Aniline hydrochloride - 10596-F

 

CASRN: 142-04-1

Related: ANILINE 62-53-3

Formula: C6-H7-N.Cl-H

Synonyms/Common Names

  • ''aniline Salt''
  • Anilinium chloride
  • Benzenamine, hydrochloride
  • Phenylamine hydrochloride
  • Phenylammonium chloride

Known Uses

Chemical intermediate; printing and dyeing of fabric and wood, aniline base occurs in coal tar (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03736)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03736)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03736)  Report Complete 
    • TR-130 (NIH Number: 78-1385)  (Peer Review Approval 06/29/1978A )
      Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN 142-04-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Salmonella  (N-9372)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
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