National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10598-n

Testing Status of 8-Hydroxyquinoline - 10598-N

 

CASRN: 148-24-3

Related: 8-HYDROXYQUINOLINE SULFATE 134-31-6; TRANSGENIC MODEL EVALUATION (8-HYD

Formula: C9-H7-N-O

Synonyms/Common Names

  • Hydroxybenzopyridine
  • Oxine
  • 8-Quinolinol

Known Uses

Reagent, antimicrobial, preservative, chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55298)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55298)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,800,12000, M: 0,400,6000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C55298)  Report Complete 
    • TR-276 (NIH Number: 85-2532)  (Peer Review Approval 03/23/1984A )
      Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CASRN 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0,1500,3000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (470651)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (592699)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • In Vitro Cytogenetics (CA/SCE)  (616445)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Drosophila  (312315)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (980523)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (375977)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (073796)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (470651)  Completed 
    • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
    • Mice
    • Sister Chromatid  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.