National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10606-p

Testing Status of Calcium cyanamide - 10606-P

 

CASRN: 156-62-7

Formula: C-H2-N2.Ca

Synonyms/Common Names

  • Cyanamide, calcium salt (1:1)

Known Uses

Fertilizer, defoliant, herbicide, pesticide; hardening iron and steel. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02937)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 400, 1500, M: 0, 1500, 30000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02937)  Report Complete 
    • TR-163 (NIH Number: 79-1719)  (Peer Review Approval 12/13/1978A )
      Bioassay of Calcium Cyanamide for Possible Carcinogenicity (CASRN 156-62-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 100, 200, M: 0, 100, 400 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (893256)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (522663)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (430294)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (035712)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 
  • Salmonella  (232717)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.