National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10607-t

Testing Status of Dibenzo-p-dioxin - 10607-T

 

CASRN: 262-12-4

Formula: C12-H8-O2

Synonyms/Common Names

  • Dibenzo(b,e)(1,4)dioxin

Known Uses

Contaminant in a germicide and a herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03656A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C03656A)  Report Complete 
    • TR-122 (NIH Number: 79-1377)  (Peer Review Approval 08/31/1978A )
      Bioassay of Dibenzo-p-dioxin for Possible Carcinogenicity (CASRN 262-12-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 5000, 10000 PPM/35R - 50M PER GROUP.
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