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Testing Status of Methyl parathion 10608-X

 

CASRN: 298-00-0

Formula: C8-H10-N-O5-P-S

Synonyms/Common Names

  • O,O-Dimethylphosphorothoic acid-o-(4-nitrophenyl)ester (9CI)

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02971)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 10, 50, M: 0, 20, 500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02971)  Completed 
    • TR-157 (NIH Number: 79-1713)  (Peer Review Approval 12/15/1978A )
      Bioassay of Methyl Parathion for Possible Carcinogenicity (CASRN 298-00-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 20, 40, MM: 0, 35, 77 (AVG), FM: 0, 62.5, 125 PPM/50 PER GROUP.

Special Studies

  • C. elegans  (S0903)  Completed 
    • C. elegans
    • Dose: feed: (0, .002, .0032, .005, .0079, .013, .02, .032, .05, .079, .13, .2) mM 2/19/06; repro: (0, .004, .005, .0063, .0079, .01, .013, .02, .025, .032, .04) mM 02/24/06 growth: (0, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100) uM 07/09/07.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (433667)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (049060)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive