National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10609-c

Testing Status of Chloral hydrate - 10609-C

 

CASRN: 302-17-0

Related: CHLORAL 75-87-6

Formula: C2-H3-Cl3-O2

Synonyms/Common Names

  • Chloraldurat
  • Lorinal
  • Noctec
  • Trichloroacetaldehyde monohydrate
  • 2,2,2-Trichloro-1,1-ethanediol

Known Uses

Medication: CNS depressant & sedative agent; in liniments; used in pediatrics; intermediate in plastics, pesticides. Also found in drinking water as result of chlorination.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Gavage)  (C92010B)  Completed 
    • Citation: Beland, F.A., Schmitt, T.C., Fullerton, N.F., and Young, J.F. (1998). Metabolism of chloral hydrate in mice and rats after single and multiple doses. J. Toxicol. Environ. Health, Part A 54, 209-226.
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
  • 2 weeks (Gavage)  (C92010)  Completed 
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: R&M: 0, 50, 100, 200, 400, OR 800 MG/KG; 8/GROUP/SEX/SPECIES.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C92010C)  Report Complete 
    • TR-503 (NIH Number: 03-4437)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CASRN 302-17-0) in Male B6C3F1 Mice (Gavage Study)
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Mice Some Evidence 
    • Dose: 0, 25, 50, OR 100 MG/KG.
  • 2 years (Gavage)  (C92010)  Report Complete 
    • TR-502 (NIH Number: 02-4436)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Female Mice Equivocal Evidence 
    • Dose: 0, 25, 50, OR 100 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (043571)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (852155)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Micronucleus  (518954)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (780474)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • single Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98034)  Completed 
    • Female Mice: SEC/E X C57B1/E
    • Dose: 400 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.