National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10610-y

Testing Status of Mexacarbate - 10610-Y

 

CASRN: 315-18-4

Formula: C12-H18-N2-O2

Synonyms/Common Names

  • 4-(Dimethylamino)-3,5-dimethylphenol methylcarbamate (ester) (9CI)

Known Uses

Insecticide; molluscicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00544)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00544)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 100, 1000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00544)  Report Complete 
    • TR-147 (NIH Number: 78-1703)  (Peer Review Approval 06/29/1978A )
      Bioassay of Mexacarbate for Possible Carcinogenicity (CASRN 315-18-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 209, 418 (AVG), FR: 0, 339, 678 (AVG), MM: 0, 327, 654 (AVG), FM: 0, 68, 135 (AVG) PPM/50 PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.