Testing Status of Sodium thioglycolate 10613-K

 

CASRN: 367-51-1

Formula: C2-H4-O2-S.Na

Synonyms/Common Names

  • Mercaptoacetic acid, monosodium salt (9CI)
  • Thioglycolic acid, sodium salt

Known Uses

Used in cold-wave hair preparations & depilatories. Also used as pharmaceutical intermediates, vinyl stabilizers, and analytical reagents. (exec sum 8/96)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C98007)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 11.25, 22.5, 45, 90, or 180 mg/kg; M: 0, 22.5, 45, 90, 180, or 360 mg/kg.
  • 13 weeks (Topical Application)  (C98007)  Completed 
    • TOX-80 (NIH Number: 16-5936)  (Tox Peer Review 12/00/2013A )
      NTP Technical Report on the Toxicity Studies of Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 11.25, 22.5, 45, 90, or 180 mg/kg; M: 0, 22.5, 45, 90, 180, or 360 mg/kg.

Genetic Toxicology

  • Micronucleus  (A85427)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (471613)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 6 to 19 GD Conventional Teratology (Topical Application)  (TER98009)  Completed 
    • Citation: Final Study Report: Developmental Toxicity Evaluation for Sodium Thioglycolate (CASRN 367-51-1) Administered Topically to Sprague-Dawley (CD®) Rats on Gestational Days 6 through 19 and Laboratory Supplement for the Final Study Report
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 100, OR 200 MG/KG/DAY.
  • 6 to 29 GD Conventional Teratology (Topical Application)  (TER99005)  Completed 
    • Citation: Developmental Toxicity Evaluation for Sodium Thioglycolate (CASRN 367-51-1) Administered Topically to New Zealand White Rabbits on Gestational Days 6 through 29
    • Female Rabbit: New Zealand White
    • Dose: 0, 10, 15, 25 OR 65 MG/KG/DAY.
  • 14 days (nonpregnant pilot); pregnant screen GD 1-19 and GD 6-19 Teratology Pilot Studies (Topical Application)  (TRP98009)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 6, 60 OR 600 MG/KG/DAY (NONPREGNANT PILOT 14 DAYS); 0, 525 MG/KG/DAY (PREGNANT SCREEN 1-19); 0, 50, 250, 350, OR 525 MG/KG/DAY (PREGNANT SCREEN 6-19).
  • 6 to 29 GD Teratology Pilot Studies (Topical Application)  (TRP99008)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 25, 50, 100, 150, OR 175 MG/KG/DAY.