National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10623-t

Testing Status of Dimethylvinyl chloride (DMVC) - 10623-T

 

CASRN: 513-37-1

Formula: C4-H7-Cl

Synonyms/Common Names

  • 1-Chloro-2-methyl-1-propene
  • DMVC

Known Uses

Chemical intermediate used in organic synthesis (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54819A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54819A)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54819A)  Report Complete 
    • TR-316 (NIH Number: 86-2572)  (Peer Review Approval 12/09/1985A )
      Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: 0,100,200 MG/KG/50 PER GROUP.
  • 2-Year (Gavage)  (C54819A)  Report Complete 
    • TR-316 (NIH Number: 86-2572)  (Peer Review Approval 12/09/1985A )
      Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0066)  Completed 
    • Citation: Ghanayem BI, Burka LT. Comparative metabolism and disposition of 1-chloro-and 3-chloro-2-methylpropene in rats and mice. Drug Metabol Dispos. 1987 Jan-Feb;15(1):91-6.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
  • Cell Proliferation (Gavage)  (S0761)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Dosed-Feed)  (S0750)  Completed 
    • Citation: Srinivas P, Burka LT. Metabolism of 1-chloro-2-methylpropene. Evidence for reactive chloroaldehyde intermediates. Drug Metab Dispos. 1988 May-Jun;16(3):449-54.Pubmed Abstract
    • Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (154330)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (758308)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (452004)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A35968)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Micronucleus  (A50288)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (327442)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Negative 
  • Salmonella  (397636)  Completed 
    • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.