Testing Status of 2-Chloroacetophenone (CN) 10625-C

 

CASRN: 532-27-4

Formula: C8-H7-Cl-O

Synonyms/Common Names

  • 2-Chloro-1-phenylethanone
  • CN

Known Uses

Riot control agent.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C55107)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Inhalation)  (C55107)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.25, 4 MG/M3/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55107)  Report Complete 
    • TR-379 (NIH Number: 90-2834)  (Peer Review Approval 11/20/1989A )
      Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CASRN 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 1, 2, M: 0, 2, 4 MG/M3/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (037856)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Weakly Positive 
  • Salmonella  (961999)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative