National Toxicology Program

National Toxicology Program

Testing Status of Methyldopa sesquihydrate - 10629-S


CASRN: 41372-08-1

Formula: C10-H13-N-O4.3/2H2-O

Synonyms/Common Names

  • 3-Hydroxy-alpha-methyl-L-tyrosine (9CI)

Known Uses

Antihypertensive agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55721)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55721)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .31, 5 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55721)  Report Complete 
    • TR-348 (NIH Number: 89-2803)  (Peer Review Approval 11/06/1987A )
      Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CASRN 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 3100, 6300, M: 0, 6300, 12500 PPM/50 PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.