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Testing Status of Glycidol 10630-P

 

CASRN: 556-52-5

Formula: C3-H6-O2

Synonyms/Common Names

  • 2,3-Epoxy-1-propanol
  • Oxiranemethanol (9CI)

Known Uses

Viscous liquid that is used as a stabilizer in the manufacture of vinyl polymers, as an additive for oil and synthetic hydraulic fluids, and as a diluent in some epoxy resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55549)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55549)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 400, M: 0, 19, 300 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55549)  Completed 
    • TR-374 (NIH Number: 90-2829)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 38, 75, M: 0, 25, 50 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0161)  Completed 
    • Citation: Nomeir AA, Silveira DM, Ferrala NF, Markham PM, McComish MF, Ghanayem BI, Chadwick M. Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J Toxicol Environ Health. 1995 Feb;44(2):203-17.Pubmed Abstract
    • Citation: Studies of Chemical Disposition in Mammals. Comparative Metabolism and Disposition of Glycidol in Rats following Oral and Intravenous Administration. July 1991.
    • Male Rats: F344/N
    • Dose: 37.5, 75 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (536149)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (381221)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (036941)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (196476)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A37837)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A48958)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A58625)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A75768)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A92101)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Positive 
    • Female Positive 
  • Salmonella  (278371)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
  • Salmonella  (971355)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM20002)  Completed 
    • Female Mice: B6C3F1
    • Dose: STUDY 1: 0, 25, 50, 75, 100, 125, 150, 200, 250, OR 300 MG/KG; STUDY 2: 0, 50, 125, 200, 300, OR 400 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM91019)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 25, 125, 250 MG/KG.
  • Preimplantation Zygote Effects (Gavage)  (PZEF49)  Completed 
    • Citation: Rutledge, J.C., Generoso, W.M., Shourbaji, A., Cain, K.T., Gans, M., and Oliva, J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutation Research 296: 167-177 (1992).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Total Reproductive Capacity (Dosed-Water)  (TRC98035)  Completed 
    • Female Mice
    • Mice Female Negative