National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10632-x

Testing Status of 3-Chloro-2-methylpropene - 10632-X

 

CASRN: 563-47-3

Formula: C4-H7-Cl

Synonyms/Common Names

  • 3-Chloro-2-methyl-1-propene

Known Uses

Fumigant. Insecticide. Intermediate in production of plastics, pharmaceuticals, herbicides & pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54820)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54820)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,50,400, M: 0,125,1250 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54820)  Report Complete 
    • TR-300 (NIH Number: 86-2556)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CASRN 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0,75,150, M: 0,100,200 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0749)  Completed 
    • Citation: Ghanayem BI, Burka LT. Comparative metabolism and disposition of 1-chloro-and 3-chloro-2-methylpropene in rats and mice. Drug Metabol Dispos. 1987 Jan-Feb;15(1):91-6.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
  • Cell Proliferation  (S0759)  Completed 
    • Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (223649)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (876278)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (087115)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (164107)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (563589)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (249137)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (154361)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (701637)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (933790)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (223649)  Completed 
    • Mice
    • Sister Chromatid  Positive 
  • Sister Chromatid Exchanges  (876278)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.