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Testing Status of Methyl carbamate 10642-F

 

CASRN: 598-55-0

Formula: C2-H5-N-O2

Synonyms/Common Names

  • Carbamic acid methyl ester (9CI)

Known Uses

Chemical intermediate for fabric finish resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55594)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55594)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 9.38, 200 MG/ML/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55594)  Completed 
    • TR-328 (NIH Number: 88-2584)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Methyl Carbamate (CASRN 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 100, 200, M: 0, 500, 1000 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0068)  Completed 
    • Citation: Ioannou YM, Sanders JM, Matthews HB. Methyl carbamate. Species-dependent variations in metabolism and clearance in rats and mice. Drug Metab Dispos. 1988 May-Jun;16(3):435-40.Pubmed Abstract
    • Male Rats: F344/N; Male Mice; Male Rats: F344/N; Male Mice
    • Dose: PO:40, 400, 1000; IV: 0.4 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (732171)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (208922)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (089158)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (694447)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Micronucleus  (432500)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (413614)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (N-9084)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251