National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10649-h

Testing Status of 4-Nitroanthranilic acid - 10649-H

 

CASRN: 619-17-0

Formula: C7-H6-N2-O4

Synonyms/Common Names

  • 2-Amino-4-nitrobenzoic acid (9CI)

Known Uses

Formerly used as dye intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01945)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01945)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.45, 1.35 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01945)  Report Complete 
    • TR-109 (NIH Number: 78-1364)  (Peer Review Approval 06/29/1978A )
      Bioassay of 4-Nitroanthranilic Acid for Possible Carcinogenicity (CASRN 619-17-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, .46, 1.5 (AVG), M: 0, .46, 1.0 (AVG) %/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (235278)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (573798)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (721150)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (027486)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (421216)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
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