Testing Status of p-Phenylenediamine dihydrochloride 10650-F

 

CASRN: 624-18-0

Formula: C6-H8-N2.2Cl-H

Synonyms/Common Names

  • 1,4-Benzenediaminedihydrochloride (9CI)

Known Uses

Hair dye

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 7 weeks (Dosed-Feed)  (C03930)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 681, 3160, M: 0, 1000, 4640 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C03930)  Report Complete 
    • TR-174 (NIH Number: 79-1730)  (Peer Review Approval 10/25/1978A )
      Bioassay of p-Phenylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 624-18-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 625, 1250 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0501)  Completed 
    • Citation: Ioannou YM, Matthews HB. p-Phenylenediamine dihydrochloride: comparative disposition in male and female rats and mice. J Toxicol Environ Health. 1985;16(2):299-313.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (921738)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (G39584)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (G80192)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Salmonella  (646507)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (N-9251)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248