National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10651-j

Testing Status of 1,1,1,2-Tetrachloroethane - 10651-J

 

CASRN: 630-20-6

Related: HALOGENATED ETHANES CS (1,1,1,2-TETRACHLOROETHANE)

Formula: C2-H2-Cl4

Synonyms/Common Names

  • Ethane, 1,1,1,2-tetrachloro- (8CI)(9CI)

Known Uses

Intermediate for producing tri- and tetra- chloroethylene

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C52459)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C52459)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 5, 500 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C52459)  Completed 
    • TR-237 (NIH Number: 83-1793)  (Peer Review Approval 12/16/1981A )
      Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 125, 250, M: 0, 250, 500 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (499400)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (592953)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (264495)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (472008)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Mouse Lymphoma  (503956)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Micronucleus  (299785)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (466226)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (806178)  Completed 
    •  Negative 
  • Sister Chromatid Exchanges  (499400)  Completed 
    • Mice
    • Sister Chromatid  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.