National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10654-w

Testing Status of o-Toluidine hydrochloride - 10654-W

 

CASRN: 636-21-5

Related: O-TOLUIDINE 95-53-4

Formula: C7-H9-N.Cl-H

Synonyms/Common Names

  • 2-Methylbenzenamine hydrochloride (9CI)

Known Uses

Dye intermediate; photographic dye; lab reagent; rubber manufacture. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 1 week (Dosed-Feed)  (C02335B)  Completed 
    • Rats: F344/N
  • 14-Day (Dosed-Feed)  (C02335)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 26 weeks (Dosed-Feed)  (C02335B)  Report Complete 
    • TOX-44 (NIH Number: 96-3936)  (Tox Peer Review 08/00/1995A )
      Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats
    • Rats: F344/N
    • Dose: O AND 0 ALTERED MICROFLORA; 20/GRP; 5000 PPM; 60/GRP.
  • 13-Week (Dosed-Feed)  (C02335)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 148 weeks (Dosed-Feed)  (C02335)  Report Complete 
    • TR-153 (NIH Number: 79-1709)  (Peer Review Approval 10/25/1978A )
      Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (938330)  Completed 
    • Mice
    •  Not a Valid Test 
  • In Vitro Cytogenetics (CA/SCE)  (867721)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Drosophila  (537539)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (885510)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (531447)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (539939)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Sister Chromatid Exchanges  (938330)  Completed 
    • Mice
    • Sister Chromatid  Positive 
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