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Testing Status of Hexamethylphosphoramide 10658-L

 

CASRN: 680-31-9

Formula: C6-H18-N3-O-P

Synonyms/Common Names

  • Hexamethylphosphoric triamide (9CI)

Known Uses

De-icing additive for jet fuels, chemosterilant

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Chromosome Aberrations  (A48570)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (088581)  Completed 
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (609861)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Mouse Lymphoma  (304965)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Positive 
  • Salmonella  (753161)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Negative 

Organ Systems Toxicity

  • Total Reproductive Capacity (Gavage)  (TRC98019)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female  +, INTERVAL 1
    • +, INTERVAL 1