National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10660-n

Testing Status of Dimethyl methylphosphonate - 10660-N

 

CASRN: 756-79-6

Formula: C3-H9-O3-P

Synonyms/Common Names

  • Methanephosphonic acid dimethyl ester

Known Uses

Flame retardant; solvent; hydraulic fluid; antifoam agent; plasticizer and stabilizer; textile conditioner and antistatic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54762)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54762)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,250,4000, M: 0,250,8000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54762)  Report Complete 
    • TR-323 (NIH Number: 88-2579)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Inadequate Study 
      • Female Mice No Evidence 
    • Dose: R: 0,500,1000, M: 0,1000,2000 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (202021)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (314062)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (212220)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (369588)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (842521)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0117)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 4175 MG/KG BODY WEIGHT.
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