National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10662-w

Testing Status of C.I. Solvent Yellow 14 - 10662-W

 

CASRN: 842-07-9

Formula: C16-H12-N2-O

Synonyms/Common Names

  • 1-(Phenylazo)-2-naphthalenol
  • Yellow 14, C.I. Solvent

Known Uses

Monoazo dye in hydrocarbon solvents, oils, fats, shoe polish, gasoline, soap

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C53929)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C53929)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 250, 4000, M: 0, 500, 4000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C53929)  Report Complete 
    • TR-226 (NIH Number: 82-1782)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Bioassay of C.I. Solvent Yellow 14 (CASRN 842-07-9) in F344/N Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 250, 500, M: 0, 500, 1000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (114547)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (247659)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (700839)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (841852)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Micronucleus  (666998)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (318291)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (916978)  Completed 
    •  Positive 
  • Sister Chromatid Exchanges  (114547)  Completed 
    • Mice
    • Sister Chromatid  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.