Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Dimethyl hydrogen phosphite 10663-A

 

CASRN: 868-85-9

Formula: C2-H7-O3-P

Synonyms/Common Names

  • Phosphonic acid, dimethyl ester

Known Uses

Intermediate. Additive to lubricants. Adhesive. Fire retardant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 400, M: 0, 95, 1500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54773)  Completed 
    • TR-287 (NIH Number: 86-2543)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MR&M: 0, 100, 200, FR: 0, 50, 100 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0081)  Completed 
    • Citation: Nomeir AA, Uraih LC. Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. Fundam Appl Toxicol. 1988 Jan;10(1):114-24.Pubmed Abstract
    • Male Rats; Male Rats: F344/N
    • Dose: PO: 200, 1000 MG/KG IV: 1000 MG/KG.
  • Mechanisms (in-vitro)  (S0502)  Completed 
    • Citation: Nomeir AA, Burka LT, Matthews HB. Analysis of dimethyl hydrogen phosphite and its stability under simulated physiological conditions. J Anal Toxicol. 1988 Nov-Dec;12(6):334-8.Pubmed Abstract

Genetic Toxicology

  • Chromosome Aberrations  (515672)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (601658)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (292004)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (199344)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (224367)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (772334)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Equivocal 
  • Salmonella  (940869)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (515672)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol)