National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10663-a

Testing Status of Dimethyl hydrogen phosphite - 10663-A

 

CASRN: 868-85-9

Formula: C2-H7-O3-P

Synonyms/Common Names

  • Phosphonic acid, dimethyl ester

Known Uses

Intermediate. Additive to lubricants. Adhesive. Fire retardant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54773)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 400, M: 0, 95, 1500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54773)  Report Complete 
    • TR-287 (NIH Number: 86-2543)  (Peer Review Approval 07/27/1984A )
      Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MR&M: 0, 100, 200, FR: 0, 50, 100 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0081)  Completed 
    • Citation: Nomeir AA, Uraih LC. Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. Fundam Appl Toxicol. 1988 Jan;10(1):114-24.Pubmed Abstract
    • Male Rats; Male Rats: F344/N
    • Dose: PO: 200, 1000 MG/KG IV: 1000 MG/KG.
  • Mechanisms (in-vitro)  (S0502)  Completed 
    • Citation: Nomeir AA, Burka LT, Matthews HB. Analysis of dimethyl hydrogen phosphite and its stability under simulated physiological conditions. J Anal Toxicol. 1988 Nov-Dec;12(6):334-8.Pubmed Abstract

Genetic Toxicology

  • Chromosome Aberrations  (515672)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (601658)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (292004)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (199344)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Micronucleus  (224367)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (772334)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Equivocal 
  • Salmonella  (940869)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (515672)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 
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