National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10669-y

Testing Status of 2-Chloroethyltrimethylammonium chloride - 10669-Y

 

CASRN: 999-81-5

Formula: C5-H13-Cl-N.Cl

Synonyms/Common Names

  • Chlorcholine chloride
  • 2-Chloro-N,N,N-trimethylethanaminium chloride

Known Uses

Plant growth regulator (Merck 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02960)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02960)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 135 weeks (Dosed-Feed)  (C02960)  Report Complete 
    • TR-158 (NIH Number: 79-1714)  (Peer Review Approval 12/13/1978A )
      Bioassay of (2-Chloroethyl)trimethylammonium Chloride (CCC) for Possible Carcinogenicity (CASRN 999-81-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,1500,3000, M: 0,500,2000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (022395)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (564198)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (899913)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (698498)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (752647)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.