National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10670-w

Testing Status of Dibutyltin diacetate - 10670-W

 

CASRN: 1067-33-0

Formula: C12-H24-O4-Sn

Synonyms/Common Names

  • Bis(acetyloxy)dibutylstannane

Known Uses

Catalyst for polymerization; stabilizer

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02028)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02028)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,70,315, M: 0,17,650 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02028)  Report Complete 
    • TR-183 (NIH Number: 79-1739)  (Peer Review Approval 10/25/1978A )
      Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CASRN 1067-33-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Inadequate Study 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,66.5,133 (AVG), M: 0,76,152 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (092968)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (373936)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (881018)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (834817)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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