National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10672-e

Testing Status of Decabromodiphenyl Ether - 10672-E

 

CASRN: 1163-19-5

Formula: C12-Br10-O

Synonyms/Common Names

  • BDE-209
  • Deca BDE
  • 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209)
  • Flame Retardant 2
  • 1,1'-Oxybis(2,3,4,5,6-pentabromobenzene)

Known Uses

Flame retardant. For nitrile resins, polyester and textile coatings.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 5 days (Gavage)  (C10672)  On Test 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
  • 14-Day (Dosed-Feed)  (C55287)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55287)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,3100,50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C55287)  Report Complete 
    • TR-309 (NIH Number: 86-2565)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0,25000,50000 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed; Intravenous)  (S0210)  Completed 
    • Citation: el Dareer SM, Kalin JR, Tillery KF, Hill DL. Disposition of decabromobiphenyl ether in rats dosed intravenously or by feeding. J Toxicol Environ Health. 1987;22(4):405-15.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: IV: 1 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (856353)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (490548)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Micronucleus  (A36713)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Salmonella  (185983)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T10672)  Assigned 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
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