National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10674-l

Testing Status of 2-Ethylhexyl Diphenyl Phosphate - 10674-L

 

CASRN: 1241-94-7

Formula: C20-H27-O4-P

Synonyms/Common Names

  • EHDP
  • 2-Ethylhexyl diphenyl ester phosphoric acid (9CI)
  • Flame Retardant 1

Known Uses

Vinyl film for food packaging

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Planned Carcinogenicity/Toxicity

  • Selected (C20716)  

    Short-Term Toxicity

    • 5 days (Gavage)  (C10674)  Completed 
      • Rats: Harlan Sprague-Dawley
      • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.

    Special Studies

    • C. elegans  (W10674)  Completed 
      • C. elegans
      • Dose: Growth: 0, 0.4, 0.63, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Repro: 0, 0.4, 0.63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Feeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

    Genetic Toxicology

    • Salmonella  (644636)  Completed 
      • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
      •  Negative 

    Toxicogenomics

    • Microarray Analysis (Gavage) Selected (T10674)  
      • Rats: Harlan Sprague-Dawley
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.