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Testing Status of 2-Ethylhexyl Diphenyl Phosphate 10674-L

 

CASRN: 1241-94-7

Formula: C20-H27-O4-P

Synonyms/Common Names

  • EHDP
  • 2-Ethylhexyl diphenyl ester phosphoric acid (9CI)
  • Flame Retardant 1

Known Uses

Vinyl film for food packaging

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C10674)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.

Special Studies

  • C. elegans  (W10674)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 0.4, 0.63, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMRepro: 0, 0.4, 0.63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • Salmonella  (644636)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Gavage)  (T10674)  Completed 
    • Rats: Harlan Sprague-Dawley