National Toxicology Program

National Toxicology Program

Testing Status of Antimony Trioxide - 10676-V


CASRN: 1309-64-4

Formula: O3-Sb2

Synonyms/Common Names

  • Antimonious oxide
  • Antimony oxide

Known Uses

Flame retardant in fabrics, resins, wood coatings; pigment & opacifier in glass, ceramics & plastic; chemical intermediate for potassium antimony tartrate; raw material on manufacture of antimony metal.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C20601)  Completed 
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 3.75, 7.5, 15, 30, or 60 mg/m3; 10/sex/species dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20601)  Report Draft 
    • TR-590   (Peer Review Approval 02/16/2016A )
      Toxicology and Carcinogenesis Studies of Antimony Trioxide (CASRN 1309-64-4) in Wistar Han Rats and B6C3F Mice (Inhalation Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 3, 10, or 30 mg/m3; 50/sex/species/concentration.

Genetic Toxicology

  • Comet Assay  (G10676C)  Completed 
    • Rats
  • Comet Assay  (G10676D)  Completed 
    • Mice
  • Micronucleus  (G10676B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (G10676)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.