Testing Status of Ethylene Glycol Monomethyl Ether (EGMME) 10681-H

 

CASRN: 109-86-4

Formula: C3-H8-O2

Synonyms/Common Names

  • EGMME
  • 2-Methoxyethanol

Known Uses

Solvent for low viscosity cellulose acetate, natural resins, alcohol soluble dyes, leather, in quick drying varnishes, enamels, nail polishes, wood stains, cellophane (Merck 1989). Manufacture photographic film, jet fuel additive, cosmetics (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C62135)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 8 weeks (Dosed-Water)  (C62135C)  Report Complete 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: R: 0, 3000, 6000 PPM /20 PER GROUP.
  • 13 weeks (Dosed-Water)  (C62135)  Report Complete 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: CORE STUDY: R: 0, 750, 1500, 3000, 4500, 6000, M: 0, 2000, 4000, 6000, 8000, 10000 PPM/ 10 PER GROUP; STOP STUDY DOSES: R: 0, 1500, 3000, 6000 PPM/ 30 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation; Topical Application)  (S0096)  Completed 
    • Citation: Sabourin PJ, Medinsky MA, Thurmond F, Birnbaum LS, Henderson RF. Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats. Fundam Appl Toxicol. 1992 Jul;19(1):124-32.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 5 & 46 PPM.
  • Absorption Disposition Metabolism Elimination (Dosed-Water)  (S0513)  Completed 
    • Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0782)  Completed 
    • Citation: Ghanayem BI, Chapin RE. Calcium channel blockers protect against ethylene glycol monomethyl ether (2-methoxyethanol)-induced testicular toxicity. Exp Mol Pathol. 1990 Jun;52(3):279-90.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 200, 300 mg egme/kg (some in combination with 1, 2, 3, or 4 doses of verapamil and diltiazem).

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM91028)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 3, 10, OR 30%.
  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83098)  Completed 
    • Citation: Ethylene Glycol Monomethyl Ether: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .5, 1.0, 2.0%; N/A; N/A.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84055)  Completed 
    • Citation: Ethylene Glycol Monomethyl Ether: Reproduction and Fertility Assessment In CD-1 Mice When Administered in Drinking Water
    • Male and Female Mice: Swiss
    • Dose: 0, 1, .25, .5, 1.0, 2.0%; 0, .1, .2, .4%; 0, .2%; 0, .1%.
  • 7 days continuous premating period Continuous Breeding (Legacy) (Dosed-Water)  (RACB86057)  Completed 
    • Citation: Ethylene Glycol Monomethyl Ether : Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB86099)  Completed 
    • Citation: Ethylene Glycol Monomethyl Ether Reproduction and Fertility Assessment in C57B1/6 Mice When Administered in Drinking Water
    • Male and Female Mice: C3H
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • 7 days continuous premating period Continuous Breeding (Legacy) (Dosed-Water)  (RACB87058)  Completed 
    • Citation: Ethylene Glycol Monomethyl Ether Reproduction and Fertility Assessment In C3H Mice When Administered in Drinking Water
    • Male and Female Mice: C57BL/6
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB88100)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Ethylene Glycol Monomethyl Ether in Sprague-Dawley Rats (Litter Five)
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; 0, .006, .012, .024, .024%; 0, .024%; 0, .006, .012, .024%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB89056)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Ethylene Glycol Monomethyl Ether in Sprague-Dawley Rats (Litter Two)
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; 0, .01, .03, .1%; 0, .01, .03, .1%; 0, .01, .03%.
  • 28 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97002)  Completed 
    • Male and Female Mice: Swiss CD-1
    • Dose: 0, 70, 250, OR 700 MG/KG/DAY.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0065A)  Completed 
    • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • Female Mice: Swiss
    • Dose: 1400 MG/KG BD WT.
  • 11 GD (plug = GD 0) Conventional Teratology (Gavage)  (T0065D)  Completed 
    • Female Mice: Swiss
    • Dose: 304 mg/kg (4.0 mmol/kg).