National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10686-d

Testing Status of Malaoxon - 10686-D

 

CASRN: 1634-78-2

Formula: C10-H19-O7-P-S

Synonyms/Common Names

  • ((Dimethoxyphosphinyl)thio)-butanedioic acid, diethyl ester (9CI)

Known Uses

Metabolite of malathion

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C08628)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C08628)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 125, 8000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C08628)  Report Complete 
    • TR-135 (NIH Number: 79-1390)  (Peer Review Approval 05/01/1979A )
      Bioassay of Malaoxon for Possible Carcinogenicity (CASRN 1634-78-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 500, 1000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (635239)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (725067)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (099462)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (566519)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (822824)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Sister Chromatid Exchanges  (635239)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
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