Testing Status of 3-Nitro-p-acetophenetide 10689-P

 

CASRN: 1777-84-0

Formula: C10-H12-N2-O4

Synonyms/Common Names

  • N-(4-Ethoxy-3-nitrophenyl)acetamide (9CI)

Known Uses

Derivative of phenacetin

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01978)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01978)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.05, .8 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01978)  Report Complete 
    • TR-133 (NIH Number: 79-1388)  (Peer Review Approval 06/29/1978A )
      Bioassay of 3-Nitro-p-Acetophenetide for Possible Carcinogenicity (CASRN 1777-84-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Negative 
    • Dose: R: 0, .18, .36 (AVG) M: 0, .73, 1.46 (AVG) %/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (320412)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (605130)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (853538)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive