National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10691-r

Testing Status of Nitrofen - 10691-R

 

CASRN: 1836-75-5

Formula: C12-H7-Cl2-N-O3

Synonyms/Common Names

  • 2,4-Dichloro-1-(4-nitrophenoxy)-benzene (9CI)

Known Uses

Pre and post emergence herbicide

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00420A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Feed)  (C00420B)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00420A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 6800, 31530, M: 0, 1180, 25520 PPM/5 PER GROUP.
  • 13-Week (Dosed-Feed)  (C00420B)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 1000, 10000, M: 0, 1780, 17800 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00420A)  Report Complete 
    • TR-184 (NIH Number: 79-1740)  (Peer Review Approval 10/25/1978A )
      Bioassay of Nitrofen for Possible Carcinogenicity (CASRN 1836-75-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 3000, 6000 PPM/50 PER GROUP.
  • 2-Year (Dosed-Feed)  (C00420B)  Report Complete 
    • TR-026 (NIH Number: 78-826)  (Peer Review Approval 09/26/1977A )
      Bioassay of Nitrofen for Possible Carcinogenicity (CASRN 1836-75-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: MR: 0, 2300, 3656 (AVG), FR: 0, 1300, 2600 (AVG), M: 0, 2348, 4696 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (363245)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (927047)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (N-9367)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.