National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10693-y

Testing Status of C.I. Acid Orange 10 - 10693-Y

 

CASRN: 1936-15-8

Formula: C16-H12-N2-O7-S2.2Na

Synonyms/Common Names

  • 4-Hydroxy-3-((4-sulfo-1-naphthalenyl)azo)-1-naphthalenesulfonic acid, disodium salt
  • Orange 10, C.I.Acid

Known Uses

Biological stain; dye for paper, wood, leather, wool, silk, inks, pencil coatings

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C53838)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C53838)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C53838)  Report Complete 
    • TR-211 (NIH Number: 88-1767)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Studies of C.I. Acid Orange 10 (CASRN 1936-15-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (295893)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (819169)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Drosophila  (697316)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (224313)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Micronucleus  (122120)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (097374)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (522424)  Completed 
    •  Equivocal 
  • Sister Chromatid Exchanges  (295893)  Completed 
    • Mice
    • Sister Chromatid  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.