National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10694-d

Testing Status of Pivalolactone - 10694-D

 

CASRN: 1955-45-9

Formula: C5-H8-O2

Synonyms/Common Names

  • 3,3-Dimethyl-2-oxetanone (9CI)

Known Uses

Intermediate for polymers

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04126)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C04126)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,316,1470, M: 0,68,316 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04126)  Report Complete 
    • TR-140 (NIH Number: 78-1395)  (Peer Review Approval 06/29/1978A )
      Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,150,300, M: 0,75,150 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (N-9254)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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