National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10696-k

Testing Status of 1,2,4,5-Tetrachlorobenzene - 10696-K

 

CASRN: 95-94-3

Formula: C6-H2-Cl4

Synonyms/Common Names

  • Benzene tetrachloride

Known Uses

Intermediate for herbicides and defoliants; insecticide; impregnant for moisture resistance; electrical insulation; temporary protection in packing.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61949)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61949)  Report Complete 
    • TOX-07 (NIH Number: 91-3126)
      Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, 1000, 2000 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0065)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (411920)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (275349)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A75526)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (235798)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Sister Chromatid Exchanges  (411920)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89010)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of 1,2,4,5-Tetrachlorobenzene in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, .05, .1, .2, .4, .6%; 0, .028, .072, .18%; N/A; 0, .072%.
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