National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10698-t

Testing Status of 1,5-Naphthalenediamine - 10698-T

 

CASRN: 2243-62-1

Formula: C10-H10-N2

Synonyms/Common Names

  • 1,5-Diaminonaphthalene (9CI)

Known Uses

Dye and drug intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03021)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03021)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.03,3.0 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03021)  Report Complete 
    • TR-143 (NIH Number: 78-1398)  (Peer Review Approval 06/29/1978A )
      Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CASRN 2243-62-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,.05,1.0, M: 0,.1,.2 %/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (531218)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (279457)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
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