National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10699-x

Testing Status of Mirex - 10699-X

 

CASRN: 2385-85-5

Formula: C10-Cl12

Synonyms/Common Names

  • 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta(cd)pentalene (9CI)

Known Uses

Pesticide, fire retardant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C06428A)  Completed 
    • Rats: F344/N
  • 26 weeks (Dosed-Feed)  (C06428A)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C06428A)  Report Complete 
    • TR-313 (NIH Number: 90-2569)  (Peer Review Approval 03/04/1987A )
      Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta[cd]pentalene) (CASRN 2385-85-5) in F344/N Rats (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: MR&FR:0,0.1,1,10,25, 50 (2ND STUDY) FR:0, 50,100 PPM/52 PER GROUP.

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0164)  Completed 
    • Citation: Yarbrough J, Cunningham M, Yamanaka H, Thurman R, Badr M. Carbohydrate and oxygen metabolism during hepatocellular proliferation: a study in perfused livers from mirex-treated rats. Hepatology. 1991 Jun;13(6):1229-34.Pubmed Abstract
    • Male Rats: Sprague Dawley

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (473171)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (109625)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.