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Testing Status of C.I. Direct Blue 15 10701-A

 

CASRN: 2429-74-5

Formula: C34-H28-N6-O16-S4.4Na

Synonyms/Common Names

  • Blue 15, C.I. Direct
  • 2,7-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt

Known Uses

Dye for silk, wool, viscose, leather, paper, cellulose fibers. Biological stain. Tint for cinematographic films.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C61290)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Water)  (C61290)  Completed 
    • Rats: F344/N
    • Dose: MR: 0, 1250, 2500, 5000, 10000, 30000 PPM (10 PER GROUP) FR: 0, 630, 1250, 2500, 5000, 10000 PPM (10 PER GROUP).

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C61290)  Completed 
    • TR-397 (NIH Number: 92-2852)  (Peer Review Approval 11/19/1990A )
      Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CASRN 2429-74-5) in F344 Rats (Drinking Water Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: RATS ONLY: 0, 630, 1250, 2500 PPM (70, 45, 75, 70 PER GROUP RESPECTIVELY).

Special Studies

  • Metabolism (Gavage)  (S0018)  Completed 
    • Citation: Lynn RK, Donielson DW, Ilias AM, Kennish JM, Wong K, Matthews HB. Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicol Appl Pharmacol. 1980 Nov;56(2):248-58.Pubmed Abstract
    • Male Rats: Sprague Dawley; Female Dog
    • Dose: DOGS: 100 MG/KG; RATS 100 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (279945)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (191506)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella Reduction  (439816)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive