National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10703-h

Testing Status of Polychlorinated biphenyl - 10703-H

 

CASRN: 1336-36-3

Formula: N/F

Synonyms/Common Names

  • 1,1'-Biphenyl, chloro derivatives

Known Uses

In electrical capacitors, transformers, vacuum pumps, gas-transmission turbines

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0080)  Completed 
    • Citation: Lutz RJ, Dedrick RL, Tuey D, Sipes IG, Anderson MW, Matthews HB. Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispos. 1984 Sep-Oct;12(5):527-35Pubmed Abstract
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0736)  Completed 
    • Citation: Abdel-Hamid FM, Moore JA, Matthews HB. Comparative study of 3,4,3',4'-tetrachlorobiphenyl in male and female rats and female monkeys. J Toxicol Environ Health. 1981 Feb;7(2):181-91.Pubmed Abstract
    • Male and Female Rats: CD; Female Monkey: Rhesus
  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0737)  Completed 
    • Citation: Morales NM, Tuey DB, Colburn WA, Matthews HB. Pharmacokinetics of multiple oral doses of selected polychlorinated biphenyls in mice. Toxicol Appl Pharmacol. 1979 May;48(3):397-407.Pubmed Abstract
    • Male Mice: Swiss CD-1
  • Metabolism (Intravenous)  (S0056)  Completed 
    • Citation: Sipes IG, Slocumb ML, Chen HS, Carter DE. 2,3,6,2',3',6'-hexachlorobiphenyl: distribution, metabolism, and excretion in the dog and the monkey. Toxicol Appl Pharmacol. 1982 Feb;62(2):317-24.Pubmed Abstract
    • Male Dog: Beagles; Monkey; Male Monkey; Dog
  • Metabolism  (S0454)  Completed 
    • Citation: Duignan DB, Sipes IG, Ciaccio PJ, Halpert JR. The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2. Arch Biochem Biophys. 1988 Nov 15;267(1):294-304.Pubmed Abstract
    • Dog
  • Metabolism (Intravenous)  (S0738)  Completed 
    • Citation: Tuey DB, Matthews HB. Use of a physiological compartmental model for the rat to describe the pharmacokinetics of several chlorinated biphenyls in the mouse. Drug Metab Dispos. 1980 Nov-Dec;8(6):397-403.Pubmed Abstract
    • Male Mice: Swiss CD-1
  • Metabolism  (S0739)  Completed 
    • Citation: Schnellmann RG, Putnam CW, Sipes IG. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl by human hepatic microsomes. Biochem Pharmacol. 1983 Nov 1;32(21):3233-9.Pubmed Abstract
    • Human (Cell Lines)
  • Metabolism  (S0741)  Completed 
    • Citation: Garner CE, Jefferson WN, Burka LT, Matthews HB, Newbold RR. In vitro estrogenicity of the catechol metabolites of selected polychlorinated biphenyls. Toxicol Appl Pharmacol. 1999 Jan 15;154(2):188-97.Pubmed Abstract
  • Other  (S0506)  Completed 
    • Citation: McKinney JD, Chae K, McConnell EE, Birnbaum LS. Structure-induction versus structure-toxicity relationships for polychlorinated biphenyls and related aromatic hydrocarbons. Environ Health Perspect. 1985 May;60:57-68.Pubmed Abstract
  • Other (Gavage)  (S0740)  Completed 
    • Citation: Morales NM, Matthews HB. In vivo binding of 2,3,6,2',3',6'-hexachlorobiphenyl and 2,4,5,2',4',5'-hexachlorobiphenyl to mouse liver macromolecules. Chem Biol Interact. 1979 Sep;27(1):99-110.Pubmed Abstract
    • Male Mice: Swiss CD-1
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.