National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10705-r

Testing Status of 2,3,5,6-Tetrachloro-4-nitroanisole - 10705-R

 

CASRN: 2438-88-2

Formula: C7-H3-Cl4-N-O3

Synonyms/Common Names

  • 1,2,4,5-Tetrachloro-3-methoxy-6-nitro- (9CI)

Known Uses

Fungicide; acaricide

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03032)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03032)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .003, .4 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03032)  Report Complete 
    • TR-114 (NIH Number: 78-1369)  (Peer Review Approval 06/29/1978A )
      Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CASRN 2438-88-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, .006, .012 %/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (997382)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Mouse Lymphoma  (665415)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (966907)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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