National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10708-d

Testing Status of Trimethylthiourea - 10708-D

 

CASRN: 2489-77-2

Formula: C4-H10-N2-S

Synonyms/Common Names

  • 1,1,3-Trimethyl-2-thiourea

Known Uses

Vulcanization; adhesives; polyethylene film; chemical intermediate; useful in a wide variety of industrial applications

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02186)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02186)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 315, 6800, M: 0, 370, 5500 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02186)  Report Complete 
    • TR-129 (NIH Number: 79-1384)  (Peer Review Approval 08/31/1978A )
      Bioassay of Trimethylthiourea for Possible Carcinogenicity (CASRN 2489-77-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 250, 500, M: 0, 500, 1000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (652396)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (724688)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (572931)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Mouse Lymphoma  (360906)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (526337)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.