Testing Status of Allyl isovalerate 10717-G

 

CASRN: 2835-39-4

Formula: C8-H14-O2

Synonyms/Common Names

  • Butanoic acid, 3-methyl-, 2-propenyl ester

Known Uses

Fragrance in cosmetics, flavoring agent in foods

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54717)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54717)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 15, 250 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54717)  Report Complete 
    • TR-253 (NIH Number: 82-2509)  (Peer Review Approval 09/22/1982A )
      Carcinogenesis Studies of Allyl Isovalerate (CASRN 2835-39-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: 0, 31, 62 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (070779)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (286848)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (279617)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (479203)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (033049)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (070779)  Completed 
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol)