National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10718-k

Testing Status of HC Red 3 - 10718-K

 

CASRN: 2871-01-4

Formula: C8-H11-N3-O3

Synonyms/Common Names

  • 2-((4-Amino-2-nitrophenyl)amino)ethanol (9CI)
  • Red 3, HC

Known Uses

Dye in semi-permanent hair dyes.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54922)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54922)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 62, 1000, M: 0, 15, 250 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54922)  Report Complete 
    • TR-281 (NIH Number: 86-2537)  (Peer Review Approval 03/29/1985A )
      Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CASRN 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Inadequate Study 
    • Dose: R: 0, 250, 500, M: 0, 125, 250 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (828169)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (063330)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (890915)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
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