National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10720-l

Testing Status of 4-Chloro-o-toluidine hydrochloride - 10720-L

 

CASRN: 3165-93-3

Formula: C7-H8-Cl-N.Cl-H

Synonyms/Common Names

  • Red Base IRGA IX

Known Uses

Dye intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02368)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 6200, 50000, M: 0, 15000, 20000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02368)  Report Complete 
    • TR-165 (NIH Number: 79-1721)  (Peer Review Approval 12/13/1978A )
      Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CASRN 3165-93-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R&FM: 0, 1250, 5000, MM: 0, 3750, 15000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (333979)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Mouse Lymphoma  (151592)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (402517)  Completed 
    •  Equivocal 
  • Salmonella  (721054)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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