National Toxicology Program

National Toxicology Program

Testing Status of 2,2-bis(Bromomethyl)-1,3-propanediol - 10722-V


CASRN: 3296-90-0


Formula: C5-H10-Br2-O2

Synonyms/Common Names

  • Pentaerythritol dibromide

Known Uses

Flame retardant for epoxy, polyester, and urethane foams. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55516A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55516A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55516B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55516C)  Report Complete 
    • TR-452 (NIH Number: 96-3368)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138 ®) (CASRN 3296-90-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 2500, 5000, OR 10000 PPM; STOP STUDY: MALES 20000 PPM; 70/GROUP M: 0, 312, 625, OR 1250 PPM; 60/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0977)  Completed 
    • Citation: Chemical Disposition in Mammals Bis-2-(bromomethyl) propane-1,3-diol (BMP). Final Report
    • Male Rats: F344/N
  • Toxicokinetic Study (Gavage; Intravenous)  (S0554)  Completed 
    • Citation: Hoehle SI, Knudsen GA, Sanders JM, Sipes IG. Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats. Drug Metab Dispos. 2009 Feb;37(2):408-16. doi: 10.1124/dmd.108.023937. Epub 2008 Nov 24.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (487287)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Positive 
  • Micronucleus  (303529)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Salmonella  (380647)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (933355)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A70660)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB85043)  Completed 
    • Citation: 2,2-Bis (Bromomethyl) -1,3-Propanediol: Reproduction and Fertility Assessment In CD-1 Mice When Administered in Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,0.025,.05,.1,.25,.5%; N/A; N/A.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.