National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10738-c

Testing Status of 2-Chloromethylpyridine hydrochloride - 10738-C

 

CASRN: 6959-47-3

Related: 3-CHLOROMETHYLPYRIDINE HYDROCHLORIDE (CAS 6959-48-4)

Formula: C6-H6-Cl-N.Cl-H

Synonyms/Common Names

  • 2-(Chloromethyl)pyridine hydrochloride

Known Uses

Intermediate for sunscreens, analgesics and anti-inflammatory agents

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C03907)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C03907)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03907)  Report Complete 
    • TR-178 (NIH Number: 79-1734)  (Peer Review Approval 06/29/1978A )
      Bioassay of 2-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CASRN 6959-47-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • Chromosome Aberrations  (145263)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (448657)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (064670)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Drosophila  (082163)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (465584)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (783983)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (861777)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A65556)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (374887)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Sister Chromatid Exchanges  (145263)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
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