National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10745-x

Testing Status of Selenium sulfide - 10745-X

 

CASRN: 7446-34-6

Related: SELSUN

Formula: S-Se

Synonyms/Common Names

  • Selenium disulfide

Known Uses

Antidandruff shampoo, glass, electronics, rubber, in treatment of fungal infections of skin (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C50033A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Topical Application)  (C50033B)  Completed 
    • Mice: Swiss
  • 13-Week (Gavage)  (C50033A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,3.2,31.6, M: 0,21.6,464 MG/KG/10 PER GROUP.
  • 13 weeks (Topical Application)  (C50033B)  Completed 
    • Mice: Swiss
    • Dose: 0,1.0,50 MG/DAY/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C50033A)  Report Complete 
    • TR-194 (NIH Number: 80-1750)  (Peer Review Approval 05/01/1979A )
      Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CASRN 7446-34-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0,3,15, M: 0,20,100 PPM/50 PER GROUP.
  • 2 years (Topical Application)  (C50033B)  Report Complete 
    • TR-197 (NIH Number: 80-1753)  (Peer Review Approval 05/01/1979A )
      Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CASRN 7446-34-6)
    • Mice: Swiss
    • Carcinogenesis Results
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,0.5,1.0 MG/DAY/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (023793)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Positive 
  • Chromosome Aberrations  (A25043)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (807686)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (610185)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (124703)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Micronucleus  (505251)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A25043)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (029359)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (023793)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Positive 
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